The Cuntrera-Caruana Mafia family is part of the Sicilian Mafia or Cosa Nostra and held a key position in the illicit drug trade and money laundering for Cosa Nostra in the 1980s and 1990s. The Italian press baptized the clan as 'The Rothschilds of the Mafia' or 'the bankers of Cosa Nostra'
Italian prosecutors described the Cuntrera-Caruana Mafia family as an "international holding … a holding which secures certain services for the Sicilian Cosa Nostra as a whole: drug-trafficking routes and channels for money laundering." The clan is "a very tight knit family group of men-of-honour, not only joined by Mafia bonds, but also by ties of blood." According to the Italian Antimafia Commission the Cuntrera-Caruana clan played a central role in international drug trafficking, extending their interests from Italy to Canada and Venezuela.
Prominent members of the clan are the brothers Liborio Cuntrera, Pasquale Cuntrera, Gaspare Cuntrera and Paolo Cuntrera. At the Caruana side there are Giuseppe Caruana, Carmelo Caruana and his son Alfonso Caruana, and Leonardo Caruana.