Introduced in: "Salvatore's Called a Meeting"
Killed in: "Sayonara Salvatore"
Salvatore Leone is the Don of the Leone Crime Family. According to GTA III's official website, Salvatore was originally from Palermo, Sicily and became Don of the family after a bloody power struggle in the mid-1980s.
Salvatore is introduced to Claude when he called a meeting with Joey Leone, Toni Cipriani and Luigi Goterelli. Early missions instruct Claude to investigate the activities of Curly Bob, who appeared to be leaking information about the Leone family's activities to the Colombian Cartel and, if found guilty, to kill him. Claude is later tasked to destroy a tanker ship that is a drug factory for the Cartel.
Salvatore is portrayed as increasingly paranoid and suspicious of everyone around him. Salvatore attempted to kill Claude with a trap, trying to establish a deal with the Colombian Cartel. Salvatore is killed by Claude after leaving Luigi's club, as instructed by Asuka Kasen to prove that Claude has finally broken ties with the Leone family.
Salvatore has an unnamed brother, whom he claimed "the police associate Salvatore with."
Salvatore Leone was voiced by Frank Vincent